Targeting voltage-gated calcium channels in neurological and psychiatric diseases.
Identifieur interne : 000187 ( Main/Exploration ); précédent : 000186; suivant : 000188Targeting voltage-gated calcium channels in neurological and psychiatric diseases.
Auteurs : Gerald W. Zamponi [Canada]Source :
- Nature reviews. Drug discovery [ 1474-1784 ] ; 2016.
English descriptors
- KwdEn :
- Animals, Calcium Channel Blockers (pharmacology), Calcium Channel Blockers (therapeutic use), Calcium Channels (metabolism), Humans, Mental Disorders (drug therapy), Mental Disorders (metabolism), Models, Neurological, Molecular Targeted Therapy (methods), Nervous System Diseases (drug therapy), Nervous System Diseases (metabolism).
- MESH :
- chemical , metabolism : Calcium Channels.
- chemical , pharmacology : Calcium Channel Blockers.
- chemical , therapeutic use : Calcium Channel Blockers.
- drug therapy : Mental Disorders, Nervous System Diseases.
- metabolism : Mental Disorders, Nervous System Diseases.
- methods : Molecular Targeted Therapy.
- Animals, Humans, Models, Neurological.
Abstract
Voltage-gated calcium channels are important regulators of brain, heart and muscle functions, and their dysfunction can give rise to pathophysiological conditions ranging from cardiovascular disorders to neurological and psychiatric conditions such as epilepsy, pain and autism. In the nervous system, calcium channel blockers have been used successfully to treat absence seizures, and are emerging as potential therapeutic avenues for pathologies such as pain, Parkinson disease, addiction and anxiety. This Review provides an overview of calcium channels as drug targets for nervous system disorders, and discusses potential challenges and opportunities for the development of new clinically effective calcium channel inhibitors.
DOI: 10.1038/nrd.2015.5
PubMed: 26542451
Affiliations:
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Le document en format XML
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Zamponi</name><affiliation wicri:level="4"><nlm:affiliation>Department of Physiology and Pharmacology, Hotchkiss Brain Institute and Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary T2N 4N1, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Physiology and Pharmacology, Hotchkiss Brain Institute and Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary T2N 4N1</wicri:regionArea><orgName type="university">Université de Calgary</orgName><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26542451</idno><idno type="pmid">26542451</idno><idno type="doi">10.1038/nrd.2015.5</idno><idno type="wicri:Area/PubMed/Corpus">000336</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000336</idno><idno type="wicri:Area/PubMed/Curation">000336</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000336</idno><idno type="wicri:Area/PubMed/Checkpoint">000336</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000336</idno><idno type="wicri:Area/Ncbi/Merge">001D69</idno><idno type="wicri:Area/Ncbi/Curation">001D69</idno><idno type="wicri:Area/Ncbi/Checkpoint">001D69</idno><idno type="wicri:Area/Main/Merge">000187</idno><idno type="wicri:Area/Main/Curation">000187</idno><idno type="wicri:Area/Main/Exploration">000187</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Targeting voltage-gated calcium channels in neurological and psychiatric diseases.</title><author><name sortKey="Zamponi, Gerald W" sort="Zamponi, Gerald W" uniqKey="Zamponi G" first="Gerald W" last="Zamponi">Gerald W. Zamponi</name><affiliation wicri:level="4"><nlm:affiliation>Department of Physiology and Pharmacology, Hotchkiss Brain Institute and Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary T2N 4N1, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Physiology and Pharmacology, Hotchkiss Brain Institute and Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary T2N 4N1</wicri:regionArea><orgName type="university">Université de Calgary</orgName><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName></affiliation></author></analytic><series><title level="j">Nature reviews. Drug discovery</title><idno type="eISSN">1474-1784</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Calcium Channel Blockers (pharmacology)</term><term>Calcium Channel Blockers (therapeutic use)</term><term>Calcium Channels (metabolism)</term><term>Humans</term><term>Mental Disorders (drug therapy)</term><term>Mental Disorders (metabolism)</term><term>Models, Neurological</term><term>Molecular Targeted Therapy (methods)</term><term>Nervous System Diseases (drug therapy)</term><term>Nervous System Diseases (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Calcium Channels</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Calcium Channel Blockers</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Calcium Channel Blockers</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Mental Disorders</term><term>Nervous System Diseases</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Mental Disorders</term><term>Nervous System Diseases</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Molecular Targeted Therapy</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Models, Neurological</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Voltage-gated calcium channels are important regulators of brain, heart and muscle functions, and their dysfunction can give rise to pathophysiological conditions ranging from cardiovascular disorders to neurological and psychiatric conditions such as epilepsy, pain and autism. In the nervous system, calcium channel blockers have been used successfully to treat absence seizures, and are emerging as potential therapeutic avenues for pathologies such as pain, Parkinson disease, addiction and anxiety. This Review provides an overview of calcium channels as drug targets for nervous system disorders, and discusses potential challenges and opportunities for the development of new clinically effective calcium channel inhibitors.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Alberta</li></region><settlement><li>Calgary</li></settlement><orgName><li>Université de Calgary</li></orgName></list><tree><country name="Canada"><region name="Alberta"><name sortKey="Zamponi, Gerald W" sort="Zamponi, Gerald W" uniqKey="Zamponi G" first="Gerald W" last="Zamponi">Gerald W. Zamponi</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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